bacteriostatic sodium chloride for botox

Using the same syringe, draw up the 4 mL of XEOMIN solution from the . Medfx Search Bacteriostatic water is sterile water with 0.9% benzyl alcohol to inhibit bacteria growth or development. May contain hydrochloric acid for pH adjustment. Botulinum neurotoxin formulations: overcoming the confusion. Not that bad Multiple Dose LifeShield Plastic Fliptop Vial. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Botulinum toxin in cancer therapy-current perspectives and limitations. Injection, USP, Bacteriostatic Any issues should be reported to accessibility@redspotinteractive.com. The pH is 5.0 (4.5 to 7.0). The distribution and excretion of sodium (Na+) and chloride (Cl) are largely under the control of the kidney which maintains a balance between intake and output. The container can be re-entered multiple times (usually by a sterile needle . BD PrecisionGlide Needle. When diluting or dissolving drugs, mix thoroughly and use promptly. SuperSharp technology uses micro-polishing to create a quadruple cut bevel for the . To access a personalized availability report specific to your institution(s), add up to 10 institutions to your account. At Hamilton Facial Plastic Surgery, we mix our Botox using bacteriostatic saline (a sterile, isotonic solution of sodium chloride in water and benzyl alcohol added as a bacteriostatic preservative). Objective: Available for Android and iOS devices. Botox physician help line, Allergan Inc, May 13, 2001) . 2023 dermalfillersworldwild . However, due to potential toxicity of benzyl alcohol . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Preservative-free Sodium Chloride Injection should be used for flushing intravascular catheters. Addition of an anesthetic agent to enhance the predictability of the effects of botulinum toxin type A injections: a randomized controlled study. Fortunately, you get the best option to deal with bacteria growth and development in medicine with bacteriostatic sodium chloride. Password reset instructions will be sent to your registered email address. Data are unavailable on the toxicity of other preservatives in this age group. For example, Dont manipulate the treated area and lie down for 3-4 hours following the treatment. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Botox can reconstituted with normal saline or with bacteriostatic normal saline. Grenda T, Grenda A, Krawczyk P, Kwiatek K. Appl Microbiol Biotechnol. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic water (BW) has a pH of about 5.7. May contain hydrochloric acid to balance/ adjust pH level. PP-INJ-USA-1160PP-INJ-USA-1160 2022 Pfizer Inc. All rights reserved. Save my name, email, and website in this browser for the next time I comment. It is harmless, but it cannot keep bacteria from developing, and thats where bacteriostatic sodium chloride comes in. Postural Orthostatic Tachycardia Syndrome, Tray of 25 Multiple-dose Plastic Fliptop Vials, ANALYSIS(0409-1966), LABEL(0409-1966), MANUFACTURE(0409-1966), PACK(0409-1966). BOTOX and BOTOX Cosmetic may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of taking BOTOX or BOTOX Cosmetic. NDC 0409-1966-12 May contain hydrochloric acid for pH adjustment, pH 5.0. Overall great product for other uses. Provide a password for the new account in both fields. Make sure you research the website before making a purchase. Can you reconstitute Botox with bacteriostatic saline? SOLD AS A PACK OF 25 x 10ml Vials NDC Number 00409-1966-12 / 00409196612 Manufacturer: Hospira Application Diluent Strength: 0.9% Bacteriostatic Sodium Chloride Single Dose Vial Storage Requirements USP Controlled Room Temperature Type Intramuscular, Intravenous, or Subcutaneous Volume 10 mL Latex Free: Latex Information indicates that natural rubber latex has not been used in the [] Acute Toxicity: (Species, Route, End Point, Dose) SODIUM CHLORIDE Rat Sub-tenon injection (eye) LC50/1hr > 42 g/m3 Rat Oral LD 50 3 g/kg Questioning the need to use Botox within 4 hours of - PubMed Last updated on Sep 21, 2022. bacteriostatic sodium chloride for botox Archives - Botox On Fillers DermAssist latex surgical gloves. Your email address will not be published. Pain Associated With Injection of Botulinum A Exotoxin Reconstituted We sell original products at a very affordable price. Prefilled Saline Flush Syringe Conservation Strategies However, diluting your vial medicine always has a risk, even with bacteriostatic water. Bacteriostatic You will never buy low-quality products from our shop because all our products are directly from the original bacteriostatic saline suppliers. Good Medically reviewed by Drugs.com. How long will sterile water last? Bacteriostatic 0.9% Sodium Chloride Injection 30ml is a sterile, multiple-dose nonpyrogenic, isotonic solution of sodium chloride (normal saline) in water for injection. Bacteriostatic The right and left forehead movement was measured and photographed at rest and during maximum contraction of the frontalis muscle prior to Botox administration and on follow-up days 14, 30, 60, 90, and 120 after injection. Average Very Poor. We inject Botox with a small Insulin syringe or 33 gauge needle . The pH range was 4.5 to 7.0. . official website and that any information you provide is encrypted TOR-BAC Bacteriostatic Sodium Chloride 0.9% contains Benzyl Alcohol 0.9% and is a highly sterile solution for injection. Physician Prescribing Information. Description. 8600 Rockville Pike 2007 Nov-Dec;23(6):433-8. doi: 10.1097/IOP.0b013e31815793b7. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol as a bacteriostatic preservative. Would you like email updates of new search results? Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Objective: To determine whether injection with botulinum toxin type A (Botox; Allergan Inc, Irvine, California) reconstituted with preservative-free saline (0.9% isotonic sodium chloride) after 2-week cold storage in a refrigerator (4 degrees C) or freezer (-20 degrees C) is less efficacious than injection with freshly reconstituted Botox. How is Botox mixed, and why is it important? - Hamilton Facial Plastic You may be surprised to know that it is all aimed at providing you better results and more comfort during your procedure. Bacteriostatic 0.9% Sodium Chloride 30ml (1) - Teleta Pharma Package insert / product label Another key difference is availability. Bacteriostatic Sodium Chloride 0.9% 30mL Multiple Dose Vial PACK OF 25 Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthetic procedures. Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. DERMALFILLERSUPPLIES.COM 2019 ALL RIGHTS RESERVED. We conducted a prospective, double-blind, randomized controlled trial at an academic facial plastic surgery practice with 40 volunteers for treatment of horizontal forehead rhytids, each acting as his or her own control. The safety and effectiveness in the pediatric population are based on the similarity of the clinical conditions of the pediatric and adult populations. Similarly, saline water has significant usage in the medical industry. The pH is 5.0 (4.5 to 7.0). 0 Main Menu . 0.9% Bacteriostatic Sodium Chloride Injection | Med-Vet International The pH is 5.0 (4.5 to 7.0). Sodium Chloride 0.9% Inj 30mL Bacteriostatic | On Sale | EntirelyPets Rx Helpful. Bacteriostatic 0.9% Sodium Chloride Injection contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol as a bacteriostatic presevative. Bacteriostatic Sodium Chloride Injection, USP is a sterile, non-pyrogenic, isotonic solution of sodium chloride (0.9 %) in water for injection. Please note this is an UNLICENSED product and as such the prescriber takes full responsibility for prescribing the medicine and for overseeing the patient's care . PDF Botox Reconstitution and Dilution Procedures Bacteriostatic 0.9% Sodium Chloride Injection 30ml is a sterile, nonpyrogenic, hypotonic solution of sodium chloride in water for injection. It is used mostly for diluting and dissolving drugs for IV injection and as a flush for intravascular catheters. We will never make you regret coming to us because all our customers are well taken care of and also make sure they are satisfied. Clin Cosmet Investig Dermatol. Description. Patients often question how their Botox is being diluted.We reconstitute our botox with 2 cc of bacteriostatic saline. Administration of an estimated 9 mL to a 6 kg neonate or infant is potentially capable of producing blood pressure changes. Bacteriostatic 0.9% Sodium Chloride Injection, USP Bacteriostatic 0.9% Sodium Chloride Injection, USP. Bacteriostatic 0.9% Sodium Chloride Injection 30ml is a sterile, multiple-dose nonpyrogenic, isotonic solution of sodium chloride . . Chloride Injection, USP, Rx only Pfizer understands your personal and health information is private. Bacteriostatic Sodium Chloride Prescribing Information - Drugs.com It happens! BD Insulin Syringe with BD Ultra-Fine Needle. Bacteriostatic Water Vs Bacteriostatic Sodium ChlorideHelp Buy the best quality bacteriostatic saline for botox for sale from the most reliable online shop shipping to all 50 states in the USA. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. Each milliliter (ml) contains sodium chloride 9 mg and 0.9% (9 mg/ml) benzyl alcohol added as a bacteriostatic preservative. Bethesda, MD 20894, Web Policies Visit www.fda.gov/MedWatch or call 1-800-FDA-1088. TOR-BAC Bacteriostatic Sodium Chloride Ampoules Solution (Single Bacteriostatic Sodium Chloride Bacteriostatic Saline for Injection 30ML Doing so will only opt you out of thePfizer Hospital US Website Texting program; you will remain opted in to any other Pfizer Inc. text message program(s) to which you separately opted in, To request more information or to obtain help, text HELP to This parenteral preparation is unlikely to pose a threat of sodium chloride or fluid overload except possibly in neonates and very small infants. We deliver in 2 days. Buy Allergan Botox without prescription online in Usa, Europe & Canada. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic sodium chloride is also used as a diluent with vacuum-dried BOTOX injections before injecting them into muscles. Created November 16, 2021 by Michelle Wheeler, PharmD . By opting into the Pfizer Hospital US Website Texting program, you consent to receive up to 30 text messages per month from Pfizer Inc, To stop receiving text messages, text STOP to We have 99% record delivery and 100% money back guarantee! 0 Botox Pharma Cart / $ 0.00. Bacteriostatic Water vs. Sterile Water: The Differences That Can Save Buy Bacteriostatic 0.9% Sodium Chloride Injection 30ml & Buy botox online, authentic dermal fillers online . ALL PRODUCTS ARE 100% AUTHENTIC FROM ORIGINAL MANUFACTURES. Use aseptic technique for single or multiple entry and withdrawal from all containers. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. In a blinded fashion each subject received freshly reconstituted Botox (control) on one side of the forehead (frontalis muscle) and 2-week-old reconstituted Botox (experimental) stored at 4 degrees C (refrigerated) or stored at -20 degrees C (frozen) on the other side. which is hereby incorporated as part of these terms, View Terms: At Hamilton Facial Plastic Surgery, we mix our Botox using bacteriostatic saline (a sterile, isotonic solution of sodium chloride in water and benzyl alcohol added as a bacteriostatic preservative). Saline water or simply salt water is a sterile solution of 0.9% of sodium chloride and pure water. The pH is 5.0 (4.5 to 7.0). Pfizer 00409196607 - McKesson Medical-Surgical Website:https://dermalfillersworldwide.com, Dermal Fillers World Wide provides a reliable and convenient way for Clinics, Medical Professionals and Wholesalers to purchase Dermal Fillers, Orthopaedics & all other Medical the quality products, and an experienced form of delivery. Buy 0.9% Bacteriostatic Sodium Chloride 30ml vials online. May contain hydrochloric acid to . The pH is 5.0 (4.5 to 7.0). Read more. So, before using it as a dilute agent, make sure to consult your healthcare provider for details on the quantity of the diluent. Forskolin: Health Benefits and Side Effects. *Disclaimer: Results will vary by person and are based upon the patient, the procedure, and the compliance with the aftercare program. What is bacteriostatic sodium chloride used for? Once you've added your institutions, you'll see them here before saving. May contain hydrochloric acid to balance/ adjust pH level. Volume 30 mL / PACK OF 25 VIALS. NDC 0409-1966-05 A humidifier is an effective way to deal with bacterial movement and multiplication. Bacteriostatic sodium chloride differs from bacteriostatic water in that it contains added NaCl; bacteriostatic water has no added sodium chloride. Each milliliter (mL) contains sodium chloride 9 g and 0.9m% (9 mg/mL) benzoyl also added as bacteriostatic preservative. You will have access to all site features but won't have access to your personalized availability report. Accessibility See PRECAUTIONS and ADVERSE REACTIONS. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol as a bacteriostatic preservative. Noncosmetic periocular therapeutic applications of botulinum toxin. . HHS Vulnerability Disclosure, Help . Be the first to review Bacteriostatic Saline, 30 ml.. May contain hydrochloric acid for pH adjustment. Vaxxen Labs Reconstitution Solution (30 mL) 2 Pack Authentic product. The semi-rigid vial is fabricated from a specially formulated polyolefin. TOR-BAC Bacteriostatic saline solution for injection 1 x 5ml ampoules. Buy 0.9%BacteriostaticSodium Chloride 30ml vials online from a set-a-side Service-Disabled Veteran-Owned Small Business medical supplies company certified with the United Stated Government on SAM.GOV today. . In terms of the effectiveness of the Botox, and the results you will achieve, studies have not shown any difference when reconstituting with nonpreserved versus preserved sterile saline. Even though the FDA approved why to reconstitute Botox is with normal saline, most doctors use saline with preservative because it hurts less when injected. 0.9% Sodium FOIA The bacteriostatic saline makes the Botox much less uncomfortable to inject as it acts as an anesthtic so we use bacteriostatic saline all of the time. Buy 0.9%BacteriostaticSodium Chloride online from a set-a-side Service-Disabled Veteran-Owned Small Business medical supplies company certified with the United Stated Government on SAM.GOV today. May contain . Individual results may vary. Date Pfizer believes supply will return to uninterrupted supply levels. Report abuse. You can add it as diluent directly through the appropriate syringe. If youre experiencing a medical issue, please contact a healthcare professional or dial 911 immediately. Normal Saline 0.9% USP for Injection (Bacteriostatic), 10ml Vial - 25/Tray Bacteriostatic 0.9% Sodium Chloride Injection 30ml is a sterile, multiple-dose nonpyrogenic, isotonic solution of sodium chloride (normal saline) in water for injection. The products discussed herein may have different product labeling in different countries. Bacteriostatic Sodium Chloride for Injection, 0.9% 2001;113 Suppl 4:20-4. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol as a bacteriostatic preservative. MeSH Pfizer Hospital US Your email address will not be published. Application Diluent The pH is 5.0 (4.5 to 7.0). Middle East Afr J Ophthalmol. The #1 Syringe Specifically Designed for Facial Esthetic Treatment! Physician Prescribing Information. An official website of the United States government. Patients reported less pain from injections of botulinum toxin A reconstituted with preserved saline than from injections reconstituted with preservative-free saline. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Buy bacteriostatic normal saline from a shop you can call your own and help spread the news worldwide to help gullible saline vendors that are new online. ArteFill vs. Juvederm: Similarities and Differences Explained, How to Manage Botulinum Toxin Complications, Voluma vs Juvederm: Target Areas, Comparison, and Recommendations, Restylane Lyft vs Juvederm: Target Areas, Comparison, and Review, The Different Types Of Dermal Fillers & What Makes Them Special, Bacteriostatic 0.9% Sodium Chloride Injection 30ml. Its not advisable to buy bacteriostatic saline for botox for sale from random websites online because you may end up with a fake product. We comply with the HONcode standard for trustworthy health information. May contain hydrochloric acid for pH adjustment, pH 5.0. Normal Saline does not require an MSDS due to it either being inherently non-toxic or non-toxic in the form, concentration, or quantity supplied by Velasco. All rights reserved. Federal government websites often end in .gov or .mil. You can add up to 10 Institutions you are affiliated with here. Botox 50 units - Dual Vials Botox/ toxins ampoule opener steel, durable easy to use View All ; Diluents BACTERIOSTATIC 0.9% SALINE 30ML BOTTLES Purified Water x 5Litre Sodium Chloride 1000ml IV Bags Sodium Chloride 500ml IV Bags Sodium Chloride IV 0.9% Inf (250ml) Sodium Chloride IV 0.9% Infusion (250ml) Tor-Bac 10x5ml Ampoules Bacteriostatic bacteriostatic saline). It is a copolymer of ethylene and propylene. Deeper lines and wrinkles need a combination approach with Botox, fillers, lasers, and microneedling/PRP. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Sodium Chloride Solution is a prescription medication solution for parenteral administration that helps to replenish fluids and electrolytes in your cat, dog or horse. Prevelle Silk vs Juvederm: Which Filler is Better? It helps with extending the shelf life of your saline water by preventing bacterial contamination and growth. The volume of the preparation to be used for diluting or dissolving any drug for injection, is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. CONTACT NOW. Login/Signup; Shop; Checkout; 0 Items. Olivia Beauty Fillers is here to deliver the products you have been searching online. Bacteriostatic 0.9% Sodium Chloride Injection containing additives should be given to a pregnant woman only if clearly needed. . Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. 2016 Dec;46(6):282-290. doi: 10.4274/tjo.57701. Bacteriostatic 0.9% Sodium Chloride Injection, USP. Bacteriostatic water can prevent bacterial growth and keep your medicines safe to use. Botox Cosmetic Dosage Guide - Drugs.com *Availability information on the site has been updated to match the current information fromthe availability report. Skip to content. Pediatric Use. Bacteriostatic sodium chloride is also used as a diluent with vacuum-dried BOTOX injections before injecting them into muscles. Careers. Benzyl alcohol, a preservative in Bacteriostatic Sodium Chloride Injection, USP has been associated with toxicity in neonates. . Bacteriostatic 0.9% Sodium Chloride Injection 30mlis a sterile, multiple-dose nonpyrogenic, isotonic solution of sodium chloride (normal saline) in water forinjection. SODIUM CHLORIDE | Pfizer Saline with Preservative May Make Botulinum Toxin A Injections Less Painful The pH is 5.0 (4.5 to 7.0). Collin Wayne. . Save my name, email, and website in this browser for the next time I comment. Bacteriostatic Sodium Chloride 0.9% 30mL Bacteriostatic 0.9% Sodium Chloride Injection, USP Pack of 25 x 10mL Merit's proprietary lines include Merit MEGA C IV (Ascorbic Acid USP Injection), B PLEX 100 Injection, CHLOROMAG (Magnesium Chloride USP Injection), and ISO13485, FDA registered facilities for devices such as MeritSet IV sets . If you have a lot of sterile water usage in your everyday life, get it from Australias top bacteriostatic water vendor. Each milliliter (ml) contains sodium chloride 9 mg and 0.9% (9 mg/ml) benzyl alcohol added as a bacteriostatic preservative. Please note this is an UNLICENSED product and as such the prescriber takes full responsibility for prescribing the medicine and for overseeing . Bacteriostatic 0.9% Sodium Chloride Injection 30ml is a sterile, multiple-dose nonpyrogenic, isotonic solution of sodium chloride (normal saline) in water for injection. Allergan Botox (1x100iu) - Botox On Fillers Bacteriostatic 0.9% Sodium Chloride Injection 30ml - Botox Wholesale (4.5 to 7.0). No significant difference was noted for any subject in the timing of onset or duration of action or the measurable reduction of forehead movement between the fresh and 2-week-old refrigerated Botox or between the fresh and 2-week-old frozen Botox. Sodium chloride in water dissociates to provide sodium (Na+) and chloride (Cl) ions. I Botox can last anywhere from 3 - 5 months. Sodium Chloride 0.9%, Bacteriostatic, Plastic, 9mg/mL, MDV, 30mL Vial We believe in quality products because it makes our customers happy and once they are happy it leads to more sales of our products which increases our revenue. Conclusions: May contain hydrochloric acid for pH adjustment. There have been no studies that I'm aware of that says the Botox is negatively affected by this. 8(b) Present Buy Bacteriostatic Sodium Chloride Online - Botox Pharma 533 E County Line Rd, #104,Greenwood, IN 46143, Copyright 2020, Marketing by Red Spot Interactive. 0.9% Sodium Rate Add to Wishlist. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection This preparation is designed for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection Each milliliter (mL) contains sodium chloride . LIFESHIELD is the trademark of ICU Medical, Inc. and is used under license. May contain hydrochloric acid for pH adjustment. Trust and see your skin or your business glow because what you order is what will be delivered. The bacteriostatic saline for injection solution's pH is 5.0 (4.5 to 7.0). You can also call customer service at 1-844-646-4398, You agree to Pfizers Privacy Policy, available at The content of this website is intended to be general information. The https:// ensures that you are connecting to the View full details Save 11 % Original price $ 55.95 Current price $ 49.95 Medefil Prefilled Sodium Chloride 0.9% IV Flush Syringes 5 mL fill in 6 mL x 60/Box Medefil Medefil MIS-1125 Prefilled Sodium Chloride 0.9% IV Flush Syringes 5 mL x 60/Box. You may be a novice or an expert when it comes to receiving Botox. Bookshelf Our internal system has to fight different types of bacteria when we drink water. If you add it to your humidifier, you can cripple the bacteria forever. 2,662. Pain difference associated with injection of abobotulinumtoxinA reconstituted with preserved saline and preservative-free saline: a prospective, randomized, side-by-side, double-blind study. Contains 25 of NDC 0409-1966-06, 20 mL Multiple-dose 2022 Jan;106(2):485-495. doi: 10.1007/s00253-021-11741-w. Epub 2021 Dec 24. Sodium chloride 0.9% is a diluent and osmotic agent which exerts its . While this method is more common when dosing children, it is also used during operational procedures for adults. Before Updated. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Saline 0.9% NaCl Bacteriostatic Sodium Chloride 10ml Vial - Non Bacteriostatic 0.9 Sodium Chloride Vial . We supply Botox, dermal fillers and mesotherapy across the USA, Canada and Europe. This is an RX product and can be purchased by licensed medical professional or by prescription only. Bacteriostatic Sodium Chloride for Injection, Bacteriostatic Sodium Chloride for injection, Bacteriostatic Sodium Chloride for botox Injection. Each milliliter (ml) contains sodium chloride 9 mg and 0.9% (9mg/ml) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic Sodium Chloride for Injection of 0.9% is a sterile, nonpyrogenic, isotonic solution of sodium chloride (saline solution) for injection. Reviewed in the United States on February 22, 2023. Botulinum toxin A (Botox) should be used within 4 hours of reconstitution with preservative-free saline (0.9% NaCl), according to the U.S. Food and Drug Administration (FDA . Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.