Applies only to oral form of both agents. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor. 1) Ganzoni AM. Interaction only with oral iron administration. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. This site complies with the HONcode standard for trust- worthy health information: verify here. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Schweiz Med Wochenschr; 100(7):301-3. Med J Aust; 193(9):525-32. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. [. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Due Date form Ultrasound Report. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. For liquid medications, also enter the value of the Medicine Concentration and choose . This cost includes the fee charged by the pharmacy. Modify Therapy/Monitor Closely. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Available for Android and iOS devices. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. 2.1 . Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia Minor (1)iron sucrose, benazepril. Schweiz Med Wochenschr; 100(7):301-3. official version of the modified score here. (3) Known hypersensitivity to Venofer. Applies only to oral form of both agents. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Corrected Sodium and Effective Osmolality. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Applies only to oral form of both agents. J Med. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Applies only to oral form of both agents. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Kumpf VJ. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] This may be helped by giving the medication more slowly or at a lower dose. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Where C= concentration of The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. We have found the lower dose to be better tolerated in the second half of gestation. Applies only to oral form of both agents. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Assure stable intravenous access to avoid extravasation. This information does not assure that this product is safe, effective, or appropriate for you. . Venofer may cause clinically significant hypotension. The dosage of Venofer is expressed in mg of elemental iron. Contact the applicable plan 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Applies only to oral form of both agents. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Applies only to oral form of both agents. Each mL contains 20 mg of elemental iron. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Fatal reactions have followed the test dose of iron dextran injection. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Venofer / Products / American Regent Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator 4. Applies only to oral form of both agents. Volume of iron product required = 25 mL. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Step 2: Calculation and administration of the maximum individual iron dose(s): . Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Formula for calculating the required dose of iron sucrose 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Treatment of anemia due to iron deficiency. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Use Caution/Monitor. Venofer may reduce the absorption of concomitantly administered oral iron preparations. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Avoid or Use Alternate Drug. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Minor/Significance Unknown. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. The above information is provided for general Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Use Caution/Monitor. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Minor/Significance Unknown. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Minor/Significance Unknown. Applies only to oral form of both agents. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. https://www.uptodate.com/ (Requires subscription). Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown. Accessed: 4/12/2011. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Use alternatives if available. Use Caution/Monitor. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). iron sucrose decreases levels of ibandronate by inhibition of GI absorption. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Jacobs P, Dommisse J. Either increases effects of the other by pharmacodynamic synergism. Dosing: (a) Divide calculated total cumulate dose . If we don't have the calculator you need we'll try to make it for you and add it to the website. Venofer (iron sucrose) dose calculator | Calculosaurus.com Intravenous iron sucrose for children with iron deficiency failing to Applies only to oral form of both agents. restrictions. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Use Caution/Monitor. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. FERAHEME Dosing & Administration - Feraheme Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. 1982;13(4):309-21. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Reactions have occurred following the first dose or subsequent doses of Venofer. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Below the form there are further instructions on how to use the calculator. Minor/Significance Unknown. Applies only to oral form of both agents. Iron Sucrose - SlideShare calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed Before using, check this product visually for particles or discoloration. Contraindicated. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Applies only to oral form of both agents. This topic . Venofer must only be administered intravenously either by slow injection or by infusion. Creating an account is free and takes less than 1 minute. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Steps on how to print your input & results: 1. Venofer Dosing and Administration Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Avoid or Use Alternate Drug. Minor/Significance Unknown. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. If we don't have the calculator you need then tell us the details and we'll make it for you. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Applies only to oral form of both agents. Medically reviewed by Drugs.com. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Applies only to oral form of both agents. PDF PRODUCT MONOGRAPH - pdf.hres.ca Use Caution/Monitor. Applies only to oral form of both agents. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. commonly, these are "preferred" (on formulary) brand drugs. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. To view formulary information first create a list of plans. Can't find what you need? PDF Iron dosing and administration in adults backgrounder Discard unused portion. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Use Caution/Monitor. Fulminant symptoms include confusion, sensation of passing out, paleness. Dosing Administration & Considerations . Avoid or Use Alternate Drug. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. . Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . 1. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Use Caution/Monitor. DailyMed - VENOFER- iron sucrose injection, solution In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was .
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